细胞外基质蛋白1抗体
规格：1mg/1ml
英文名： ECM1
别名： Secretory Component Glycoprotein; ECM 1; Ecm1; ECM1_HUMAN; Extracellular matrix protein 1; Secretory component p85.
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ECM1
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞外基质蛋白1抗体细胞定位：分泌型蛋白
产品介绍：background: Extracellular matrix protein 1 (ECM1) This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Function: Involved in 细胞外基质蛋白1抗体endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. Subunit: Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis. DISEASE: Lipoid proteinosis (LiP) [MIM:247100]: Rare autosomal recessive disorder characterized by细胞外基质蛋白1抗体 generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. Note=The disease is caused by mutations affecting the gene represented in this entry. Gene ID: 1893 Database links: Entrez Gene: 1893 Human Entrez Gene: 116662 Rat GenBank: NP_073155 Human Omim: 602201 Human SwissProt: Q16610 Human SwissProt: Q62894 Rat Unigene: 81071 Human Unigene: 97792 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ECM1是一种分泌性糖蛋白，ECM1可促进血管内皮细胞的增殖和血管的生成, 经研究发现，ECM1的表达可能与肿瘤及肿瘤的转移有关联, 而目前在多种肿瘤的研究中也已确认细胞外基质与肿瘤的发生、发展及转移等有密切的关系, ECM1是目前肿瘤研究的热点。
细胞外基质蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid