基质细胞衍生因子－1抗体
规格：1mg/1ml
英文名： SDF1 beta
别名： Chemokine (C X C motif) ligand 12; Chemokine (CXC motif) ligand 12; CXCL 12; CXCL12; hIRH; IRH; PBSF; Pre B cell growth stimulating factor; SCYB 12; SCYB12; SDF 1; SDF 1 beta; SDF 1a; SDF 1b; SDF1; SD
分子量： 8kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SDF-1(32
交叉反应：Human, Mouse, Rat, Chicken, Dog, Rabbit,
细胞定位：分泌型蛋白
基质细胞衍生因子－1抗体产品介绍：background: This gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]. Function: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor基质细胞衍生因子－1抗体 for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Subunit: Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of CXCR7. Subcellular Location: Secreted. Tissue Specificity: Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney,基质细胞衍生因子－1抗体 liver and spleen. Post-translational modifications: Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. Gene ID: 6387 Database links: Entrez Gene: 6387 Human Entrez Gene: 20315 Mouse Entrez Gene: 24772 Rat SwissProt: P48061 Human SwissProt: P40224 Mouse Omim: 600835 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 基质细胞衍生因子－1(SDF-1)又称趋化因子CXCL12 是小分子的细胞因子，属于趋化因子蛋白家族。它有两种形式, SDF-1α/CXCL12a和SDF-1β/CXCL12b。趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构。****半胱氨酸残基之间隔着一个介入氨基酸残基。 基质细胞源性生长因子1:趋化因子CXCL12对**细胞有强烈的趋化作用并在发育中起重要作用。在胚胎发育中CXCL12引导造血干细胞从胎儿肝脏到骨髓的迁徙。 CXCL12可以在许多组织(包括脑,胸腺,心,肺,肝,肾,骨髓,脾脏)中表达。 趋化因子CXCL12的受体是CXCR4。但是,*近有人认为CXCL12还可以与CXCR7受体结合。
基质细胞衍生因子－1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 趋化因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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