唾液酸结合性**球蛋白样凝集素1抗体
规格：1mg/1ml
英文名： Sialoadhesin
别名： CD169; CD 169; CD-169; CD169 antigen; dJ1009E24.1; DKFZp667F058; FLJ00051; FLJ00055; FLJ00073; FLJ00411; FLJ32150; Sialic acid binding Ig like lectin 1; Sialic acid binding immunoglobulin like lectin
分子量： 186kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse CD169
交叉反应：Mouse, Rat,
细胞定位：细胞膜 分泌型蛋白
唾液酸结合性**球蛋白样凝集素1抗体产品介绍：background: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]. Function: Acts as an endocytic receptor mediating clathrin dependent endocytosis.唾液酸结合性**球蛋白样凝集素1抗体 Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Subunit: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Subcellular Location: Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 16 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 唾液酸结合性**球蛋白样凝集素1抗体Ig-like V-type (immunoglobulin-like) domain. Gene ID: 6614 Database links: Entrez Gene: 6614 Human Entrez Gene: 20612 Mouse Omim: 600751 Human SwissProt: Q9BZZ2 Human SwissProt: Q62230 Mouse Unigene: 31869 Human Unigene: 1374 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD169，又称sialoadhesin（Sn）或Siglee-1，这是一种200kDa的I型跨膜糖蛋白，由炎性巨噬细胞特异性表达，在细胞-细胞或细胞-基质的相互作用中发挥主要作用。可识别乳癌细胞的MUC1（CD227）和T细胞的CD43。CD169在脾、**结、骨髓的基质巨噬细胞上表达*强，在肝、肠、肺的长驻巨噬细胞上中等表达，慢性炎组织的巨噬细胞，例如类风湿性滑膜、动脉粥样硬化性斑块，也强烈表达CD169。
唾液酸结合性**球蛋白样凝集素1抗体产品应用：IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 微生物学 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid