血管生成素-1抗体
规格：1mg/1ml
英文名： Angiopoietin-1
别名： ANG; AGP 1; AGP1; AGPT; ANG 1; ANG1; Angiopoietin1; Angiogenin; ANGPT 1; ANGPT1; ANGPT-1; Angiopoietin-1; Angiopoietin 1; ANG-1; angiopoietin-1 isoform 1 precursor; ANGP1_HUMAN.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Angiopoi
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
血管生成素-1抗体细胞定位：分泌型蛋白
产品介绍：background: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability,血管生成素-1抗体 and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]. Function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation 血管生成素-1抗体of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Subunit: Homooligomer. Interacts with TEK/TIE2. Subcellular Location: Secreted. Post-translational modifications: Glycosylated. Similarity: Contains 1 fibrinogen C-terminal domain. Gene ID: 284 Database links: Entrez Gene: 284 Human Entrez Gene: 11600 Mouse Omim: 601667 Human SwissProt: Q15389 Human SwissProt: O08538 Mouse Unigene: 369675 Human Unigene: 309336 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ang1/2与血管生成关系*为密切,目前有关该家族成员在肿瘤血管生成中的研究正日益增多。近年来也用于糖尿病导致的血管损伤研究也是热门课题。
血管生成素-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid