CX3CL1抗体
规格：1mg/1ml
英文名： CX3CL1
别名： C3Xkine; Chemokine C X3 C motif ligand 1; Chemokine CX3C Motif Ligand 1; CX3C membrane anchored chemokine; CXC 3; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; NTN; NTT; SCYD 1; SCYD1; Small inducible c
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CX3CL1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 分泌型蛋白
CX3CL1抗体产品介绍：background: CX3CL1 is a member of the delta chemokine subfamily that contains a unique CX3C cysteine motif near the N-terminal. Unlike other known chemokines, it is a type 1 membrane protein containing a chemokine domain tethered on a long mucin-like stalk. CX3CL1, a leukocyte chemoattractant, is expressed in various tissues including the brain, heart, lung, kidney, skeletal muscle, and testis. The expression is reported to be up-regulated in endothelial cells and microglia by inflammatory signals. CX3CR1, a specific receptor for fractalkine, mediates both leukocyte migration and adhesion. Function: The soluble form is chemotactic for T-cells and monocytes, but not for CX3CL1抗体neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Subunit: Monomer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Processed fractalkine: Secreted. Tissue Specificity: Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Post-translational modifications: A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form. O-glycosylated with core 1 or possibly core 8 glycans. Similarity: Belongs to the intercrine delta family. Gene ID: 6376 Database links: CX3CL1抗体Entrez Gene: 6376 Human Entrez Gene: 20312 Mouse Entrez Gene: 89808 Rat Omim: 601880 Human SwissProt: P78423 Human SwissProt: O35188 Mouse SwissProt: O55145 Rat Unigene: 531668 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经趋化蛋白cx3cl1**应答应答及细胞附着，参与细胞因子和趋化因子介导信号转导、**细胞趋化性、调控炎症应答反应、白细胞附着激活、正调控钙非依赖细胞附着。
CX3CL1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid