黑色素瘤相关抗原抗体
规格：1mg/1ml
英文名： MAGE-1
别名： MAGE-1 protein; Antigen MZ2 E; MAGE 1 antigen; MAGE1; MAGE1A; MAGEA1; Melanoma antigen 1; Melanoma antigen family A 1 (directs expression of antigen MZ2 E); Melanoma antigen family A 1; Melanoma antig
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAGE-1
交叉反应：Human,
细胞定位：细胞浆
黑色素瘤相关抗原抗体产品介绍：background: The MAGE 1 gene is a member of the melanoma antigen encoding gene family. These genes encode for HLA-restricted tumor associated rejection antigens recognized by cytotoxic T lymphocytes. 黑色素瘤相关抗原抗体Some of these target antigens may be potentially useful for cancer specific immunotherapy. The expression of MAGE genes has been reported not only in melanoma but also in various other malignant tumors such as hepatocellular carcinoma and germ cell tumors. Function: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Subunit: Interacts with SNW1 and HDCA1. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. Similarity: Contains 1 MAGE domain. Gene ID: 4100 黑色素瘤相关抗原抗体Database links: Entrez Gene: 4100 Human Entrez Gene: 17137 Mouse Entrez Gene: 493750 Rat Omim: 300016 Human SwissProt: P43355 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Mage-1表达于正常的黑素细胞和大多数原发及转移的黑色素瘤中，故称：黑色素瘤相关抗原。MAGE-1是重要的肿瘤特异性抗原-MAGE家族成员,近年被认为是一种辨别黑色素病变的有效抗原。 主要用于恶性肿瘤方面的研究。MAGE-1基因属于黑色素瘤抗原编码基因家族，其编码产物表达于各种组织类型的肿瘤中。包括黑色素瘤、神经胶质脑肿瘤、成神经细胞瘤、肾细胞癌等，但正常组织表达量较少货没有。
黑色素瘤相关抗原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid