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甲状腺核转录因子-1抗体

甲状腺核转录因子-1抗体
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  • 产品名称:甲状腺核转录因子-1抗体
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简单介绍
甲状腺核转录因子-1抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。甲状腺核转录因子-1抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。
产品描述

甲状腺核转录因子-1抗体

规格:1mg/1ml

英文名: TTF1

别名: AV026640; BCH; Benign chorea; BHC; Homeobox protein NK 2 homolog A; Homeobox protein NK-2 homolog A; Homeobox protein Nkx 2.1; Homeobox protein Nkx-2.1; Homeobox protein Nkx2.1; NK 2; NK 2 homolog A;

分子量: 38kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human TTF-1

交叉反应:Human, Mouse, Rat,

细胞定位:细胞核

甲状腺核转录因子-1抗体产品介绍:background: This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Apr 2011] Function: Transcription factor that binds and 甲状腺核转录因子-1抗体activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Subcellular Location: Nucleus. Tissue Specificity: Thyroid and lung. Post-translational modifications: Phosphorylated on serine residues by STK3. DISEASE: Chorea, hereditary benign (BHC) [MIM:118700]: A rare autosomal dominant movement disorder, defined by early onset in childhood, a stable or non-progressive course of chorea, and no mental deterioration. Chorea is characterized by involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Note=The disease is caused by mutations affecting the gene represented in this entry. Choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction (CAHTP) [MIM:610978]: An autosomal dominant disorder that manifests in甲状腺核转录因子-1抗体 infancy with neurological disturbances, hypothyroidism, and respiratory problems. It is characterized by movement abnormalities beginning with muscular hypotonia followed by the development of chorea, athetosis, dystonia, ataxia, and dysarthria. {ECO:0000269|PubMed:11854318, Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the NK-2 homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 7080 Database links: Entrez Gene: 7080 Human Entrez Gene: 21869 Mouse Entrez Gene: 25628 Rat Omim: 600635 Human SwissProt: P43699 Human SwissProt: P50220 Mouse SwissProt: P23441 Rat Unigene: 94367 Human Unigene: 89972 Mouse Unigene: 34265 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 同源结构域蛋白(Homeodomain Proteins) TTF-1存在于肺和大脑的一些区域内;包括垂体,甲状旁腺和甲状腺旁细胞中也有表达。 TTF-1有调节甲状腺、肺和大脑的基因表达的功能。它在甲状腺中的分子靶点是甲状腺球蛋白、促甲状腺素受体和甲状腺过氧化酶。 TTF1在肺腺癌和肺神经***肿瘤(包括有肺小细胞癌)中是较好的标记物之一。其特异性和敏感性都很高,可以用于区分肺原发性、继发性腺癌、小部分胃肠道腺癌等。

甲状腺核转录因子-1抗体产品应用:WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:肿瘤  细胞生物  转录调节因子  表观遗传学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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