蛋白酶激活受体-1抗体
规格：1mg/1ml
英文名： Thrombin receptor/ PAR1
别名： SAR; BXR; Proteinase-activated receptor 1 precursor; Thrombin receptor; Coagulation factor II receptor; D15S227E; Prader-Willi/Angelman region-1; PAR1; Coagulation factor II receptor; CF2R; Coagulatio
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAR1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
蛋白酶激活受体-1抗体产品介绍：background: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq, Jul 2008] Function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. Subcellular Location: Cell membrane; Multi-pass membrane protein.蛋白酶激活受体-1抗体Tissue Specificity: Platelets and vascular endothelial cells. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 2149 Database links: Entrez Gene: 2149 Human Omim: 187930蛋白酶激活受体-1抗体 Human SwissProt: P56488 Baboon SwissProt: P25116 Human Unigene: 482562 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PAR蛋白全称为蛋白酶体活化受体(Protease-activated receptors)，又称：凝血酶受体(Thrombin Receptor)是独立家族的G蛋白偶联受体， 研究认为与炎症，实体肿瘤等密切相关。 PAR1蛋白是乳腺癌细胞侵润和迁移的必需因子，它是作为基质金属蛋白酶体1（MMP-1）的受体关键性作用，这一研究结果为研制新的****提供新的靶点。
蛋白酶激活受体-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid