S100A1抗体
规格：1mg/1ml
英文名： S100A1
别名： S100A1; S-100 protein alpha subunit; S-100 protein alpha chain; Protein S100-A1; S100 calcium-binding protein A1; S100 alpha; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human S100A1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：
S100A1抗体产品介绍：background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule S100A1抗体assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008] Function: Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Subunit: Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity. Subcellular Location: CytoplasmS100A1抗体. Tissue Specificity: Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Similarity: Belongs to the S-100 family. Contains 2 EF-hand domains. Gene ID: 6271 Database links: Entrez Gene: 6271 Human Entrez Gene: 20193 Mouse Entrez Gene: 295214 Rat Omim: 176940 Human SwissProt: P23297 Human SwissProt: P56565 Mouse SwissProt: P35467 Rat Unigene: 515715 Human Unigene: 24662 Mouse Unigene: 11091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 星型胶质细胞标志物 S100A1是钙结合蛋白家族S100亚家族中一个小分子量的酸性蛋白，对稳定蛋白质分子的构象起到一定的作用。
S100A1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid