黑色素瘤生长刺激活性蛋白α抗体
规格：1mg/1ml
英文名： GRO Alpha
别名： CINC1; GRO-1; CXCL1; C-X-C motif chemokine 1; CALC 1; CALCA; Calcitonin related polypeptide alpha; Catacalcin; CGRP I; CGRP1; CGRPI; Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activ
分子量： 11.7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRO Alph
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 分泌型蛋白
黑色素瘤生长刺激活性蛋白α抗体产品介绍：background: The GRO gene was originally identified by subtractive hybridization studies between normal and tumorigenic Chinese hamster embryo fibroblasts. The hamster cDNA was cloned and used as a probe for cloning of the human GRO cDNA. The GROalpha gene initially cloned from T24 cells and the gene in melanoma cells encoding melanoma growth stimulating protein (MGSA) are identical. Human cells contain three closely related, but distinct GRO genes: GRO alpha, GRO beta, and GRO gamma. GRO beta and GRO gamma share 93% and 82% identity, respectively, with GRO alpha at the nucleotide level. GROs are members of the chemokine alpha family that is characterized by the separation with one amino acid of the first two cysteine residues, C-X-C, in the amino acid sequence.黑色素瘤生长刺激活性蛋白α抗体 The GRO gene has been mapped to chromosome 4q21. In normal cells, human mRNA GRO expression is found in foreskin fibroblasts, synovial fibroblasts, chondrocytes and osteocytes. Additionally, GRO mRNA has been detected in mammary fibroblasts, mammary epithelial cells, endothelial cells, activated monocytes, macrophages, and neutrophils. Characterization of the GROalpha receptor indicates the presence of low and high affinity receptors on human neutrophils. Function: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Subcellular Location: Secreted. Post-translational modifications: N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73)黑色素瘤生长刺激活性蛋白α抗体 and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. Gene ID: 2919 Database links: Entrez Gene: 2919 Human Entrez Gene: 14825 Mouse Entrez Gene: 81503 Rat Omim: 155730 Human SwissProt: P09341 Human SwissProt: P12850 Mouse SwissProt: P14095 Rat Unigene: 708652 Human Unigene: 789 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生长调节致癌基因α/黑素瘤生长刺激因子α；
黑色素瘤生长刺激活性蛋白α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid