DEK癌基因结合蛋白
规格：1mg/1ml
英文名： DEK
别名： D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DNA binding; DEK_HUMAN; OTTHUMP; Protein DEK.
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DEK
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow,
细胞定位：
DEK癌基因结合蛋白产品介绍：background: The DEK gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA which then induces positive supercoils into closed circular DNA, and is also involved during mRNA processing in splice site selection. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. DEK癌基因结合蛋白Function: Involved in chromatin organization. Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. Subcellular Location: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Tissue Specificity: Ubiquitous. Expressed at relatively high levels. Post-translational modifications: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle DEK癌基因结合蛋白with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. DISEASE: Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene. Similarity: Contains 1 SAP domain. Gene ID: 7913 Database links: Entrez Gene: 7913 Human Entrez Gene: 110052 Mouse Entrez Gene: 306817 Rat Omim: 125264 Human SwissProt: P35659 Human SwissProt: Q7TNV0 Mouse SwissProt: Q6AXS3 Rat Unigene: 484813 Human Unigene: 131150 Mouse Unigene: 25099 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DEK癌基因结合蛋白，主要参与DNA核转录。目前多用于白血病及急性髓系白血病的研究。
DEK癌基因结合蛋白产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid