蛋白激酶N2抗体
规格：1mg/1ml
英文名： PKN2
别名： protein kinase N2; Serine/threonine-protein kinase N2; Protein kinase C-like 2; Protease-activated kinase 2; PAK-2; Cardiolipin activated protein kinase Pak2; MGC150606; MGC71074; PAK2; PRK2; PRKCL2;
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PKN2
交叉反应：Human, Mouse, Rat,
蛋白激酶N2抗体细胞定位：细胞核
产品介绍：background: Protein-kinase-C-related kinases (PRKs) are part of the lipid-regulated protein kinases (PKC) which also include liver PAK & PKN. Human PRK1 and PRK2 share structurally similar catalytic domains, but less similar N-terminal regulatory regions suggesting different regulatory domain functions. PRK1 and PRK2, as well as a third member of this family, PRK3, show distinct patterns of expression in ***** tissues. Additionally, the serine-threonine kinase PRK2 can be specifically cleaved by caspase-3 (and/or caspase-3-like subfamily members)蛋白激酶N2抗体 during apoptosis Function: Involved in chromatin organization. Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA. Subcellular Location: Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. Tissue Specificity: Ubiquitous. Expressed at relatively high levels. Post-translational modifications: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. DISEASE: Note=A chromosomal aberration蛋白激酶N2抗体 involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene. Similarity: Contains 1 SAP domain. Gene ID: 5586 Database links: Entrez Gene: 5586 Human Entrez Gene: 109333 Mouse Entrez Gene: 207122 Rat Omim: 602549 Human SwissProt: Q16513 Human SwissProt: Q8BWW9 Mouse SwissProt: O08874 Rat Unigene: 440833 Human Unigene: 244236 Mouse Unigene: 30325 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 激酶和磷酸酶
蛋白激酶N2抗体产品应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid