促卵泡刺**受体抗体
规格：1mg/1ml
英文名： FSH receptor
别名： Follicle-stimulating hormone receptor precursor; Follicle stimulating hormone receptor; Follicle stimulating hormone receptor isoform 1; Follitropin receptor; FSHRO; LGR1; ODG1; Follicle-stimulating h
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FSHR 225
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
细胞定位：细胞膜
促卵泡刺**受体抗体产品介绍：background: The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] Function: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Subunit: Interacts with ARRB2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Sertoli cells and ovarian granulosa cells. DISEASE: Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1) [MIM:233300]; also known as premature ovarian failure 促卵泡刺**受体抗体or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Similarity: Belongs to the促卵泡刺**受体抗体 G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. Gene ID: 2492 Database links: Entrez Gene: 281172 Cow Entrez Gene: 100861291 Goat Entrez Gene: 2492 Human Entrez Gene: 14309 Mouse Entrez Gene: 397679 Pig Entrez Gene: 25449 Rat Entrez Gene: 443299 Sheep Omim: 136435 Human SwissProt: P35376 Cow SwissProt: P23945 Human SwissProt: P35378 Mouse SwissProt: P49059 Pig SwissProt: P20395 Rat SwissProt: P35379 Sheep Unigene: 1428 Human Unigene: 57155 Mouse Unigene: 162843 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FSHR属于G蛋白偶联受体超家族中的糖蛋白亚家族成员，跨膜蛋白。人类的FSHR是由695个氨基酸组成的一条肽链。主要分布于睾丸支持细胞和卵巢颗粒细胞，成熟的FSHR蛋白分子质量为：75kDa。
促卵泡刺**受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid