速激肽受体3抗体
规格：1mg/1ml
英文名： TACR3
别名： MGC148060; MGC148061; Neurokinin B receptor; Neuromedin K Receptor; Neuromedin-K receptor; NK 3 receptor; NK-3 receptor; NK-3R; NK3 receptor; NK3R; NK3R_HUMAN; NK 3R; NK3 receptor; NK3R; NKR; TAC 3R;
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TACR3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：
速激肽受体3抗体产品介绍：background: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008] Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. Subcellular Location: Cell membrane; Multi-pass membrane protein. 速激肽受体3抗体Post-translational modifications: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. DISEASE: Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) [MIM:614840]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons.速激肽受体3抗体 In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 6870 Database links: Entrez Gene: 6870 Human Entrez Gene: 21338 Mouse Omim: 162332 Human SwissProt: P29371 Human SwissProt: P47937 Mouse Unigene: 942 Human Unigene: 103810 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. P物质和NK同属于速激肽家族，而速激肽受体有NK-1、NK-2和NK-3，其中P物质与NK-1的亲和力*强。
速激肽受体3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid