NK细胞受体2D抗体
规格：1mg/1ml
英文名： NKG2D
别名： KLRK1; natural killer cell group 2D; NKG2-D isoform b; Klrk1; Nkrp2; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfa
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NKG2D
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
NK细胞受体2D抗体产品介绍：background: This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010] Function: Receptor for MICA, MICB, NK细胞受体2D抗体ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. Subunit: Homodimer. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs). Similarity: Contains 1 C-type lectin domain. Gene ID: 22914 Database links: Entrez Gene: 100528032 Human Entrez Gene: NK细胞受体2D抗体22914 Human Entrez Gene: 27007 Mouse Entrez Gene: 24934 Rat Omim: 611817 Human SwissProt: P26718 Human SwissProt: O54709 Mouse SwissProt: O70215 Rat Unigene: 387787 Human Unigene: 8217 Mouse Unigene: 14544 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NKG2-D出现在**细胞上表达的受体，NKG2D属C型凝集素家族跨膜蛋白，广泛表达在NK细胞、CD8+的αβT细胞和γδT细胞表面，可以提高NK细胞对肿瘤细胞的杀伤活性。
NK细胞受体2D抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid