褪黑素受体1B抗体
规格：1mg/1ml
英文名： MTNR1B
别名： MT2;melatonin receptor type 1B;melatonin receptor;MEL1B;MTNR1B;MEL-1B-R;Mtnr1b;MGC129286;MGC129287; MTNR-1B; Melatonin receptor 1B; MTR1B_HUMAN.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTNR1B
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
褪黑素受体1B抗体产品介绍：background: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in褪黑素受体1B抗体 circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in retina and less in brain and hippocampus. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 褪黑素受体1B抗体4544 Database links: Entrez Gene: 4544 Human Omim: 600804 Human SwissProt: P49286 Human Unigene: 569039 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有学者认为：MTNR1B是组成控制褪黑**信号通路的一部分。 褪黑**调解人体的昼夜节律，是通过白天和黑夜来控制睡眠和饮食的内部时钟。MTNR1B的进一步研究为高血糖和糖尿病与昼夜节律遭到破坏有直接关系这一观点提供了证据。
褪黑素受体1B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 生长因子和** 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid