2’,3’-环腺苷酸-3’-磷酸二酯酶抗体

2’,3’-环腺苷酸-3’-磷酸二酯酶抗体

规格：1mg/1ml

英文名： CNPase

别名： 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; Cnp; Cnp-1; Cnp1; 2''; 2'3' cyclic nucleotide 3' phosphodiesterase; 2'3'-cyclic-nucleotide 3'-phosphodiesterase; 3''-cyclic-nucleotide 3''-phospho

分子量： 48kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human CNPase

交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit, Bovine,

细胞定位：细胞膜

2’,3’-环腺苷酸-3’-磷酸二酯酶抗体产品介绍：background: 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase). This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable 2’,3’-环腺苷酸-3’-磷酸二酯酶抗体of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins. Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Subunit: Exists as monomers and homodimers. Subcellular Location: Membrane. Melanosome2’,3’-环腺苷酸-3’-磷酸二酯酶抗体. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. Gene ID: 1267 Database links: Entrez Gene: 280752 Cow Entrez Gene: 607694 Dog Entrez Gene: 1267 Human Entrez Gene: 12799 Mouse Entrez Gene: 493772 Pig Entrez Gene: 25275 Rat Omim: 123830 Human SwissProt: P06623 Cow SwissProt: P09543 Human SwissProt: P16330 Mouse SwissProt: P18104 Pig SwissProt: P13233 Rat SwissProt: P56283 Sheep Unigene: 273621 Human Unigene: 15711 Mouse Unigene: 31762 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

2’,3’-环腺苷酸-3’-磷酸二酯酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：神经生物学  细胞类型标志物  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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