基质金属蛋白酶18/19抗体
规格：1mg/1ml
英文名： MMP19
别名： Matrix metalloproteinase 18; Matrix metalloproteinase 19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; MMP 18; MMP 19; MMP-18; MMP-19; MMP18; MMP19; MMP19_H
分子量： 59kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMP19
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞外基质 分泌型蛋白
基质金属蛋白酶18/19抗体产品介绍：background: This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013] Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage基质金属蛋白酶18/19抗体 oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients. Post-translational modifications: Activated by autolytic cleavage after Lys-97. DISEASE: 基质金属蛋白酶18/19抗体Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients. Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Gene ID: 4327 Database links: Entrez Gene: 4327 Human Entrez Gene: 304608 Rat Omim: 601807 Human SwissProt: C0M4B0 Human SwissProt: Q99542 Human Unigene: 154057 Human Unigene: 591033 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
基质金属蛋白酶18/19抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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