粒细胞-巨噬细胞集落刺激因子受体α抗体
规格：1mg/1ml
英文名： GM-CSFR alpha
别名： GM-CSF Receptor alpha; CD116; CD116 antigen; Colony Stimulating Factor 2 Receptor Alpha; Colony stimulating factor 2 receptor alpha chain; CSF 2R; CSF2RA; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM CSF R al
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GM-CSFR
交叉反应：Human, Dog, Cow, Horse,
细胞定位：细胞膜 分泌型蛋白
粒细胞-巨噬细胞集落刺激因子受体α抗体产品介绍：background: The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq]. Function: Low affinity receptor for granulocyte-macrophage colony-stimulating factor. 粒细胞-巨噬细胞集落刺激因子受体α抗体Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted (Probable). Isoform 4: Secreted (Probable). Isoform 6: Secreted (Probable). DISEASE:粒细胞-巨噬细胞集落刺激因子受体α抗体 Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4) [MIM:300770]. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Similarity : Belongs to the type I cytokine receptor family. Type 5 subfamily. Database links: Entrez Gene: 1438 Human Entrez Gene: 12982 Mouse Omim: 306250 Human SwissProt: P15509 Human SwissProt: Q00941 Mouse Unigene: 520937 Human Unigene: 287228 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粒细胞-巨噬细胞集落刺激因子受体α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 干细胞 细胞表面分子 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid