唾液酸结合性**球蛋白样凝集素7抗体
规格：1mg/1ml
英文名： SIGLEC7
别名： Sialic Acid Binding Ig-Like Lectin 7; AIRM1; QA79 Membrane Protein; SIGLEC-7; D-Siglec; AIRM-1; CDw328; P75; Sialic Acid Binding Ig-Like Lectin 19, Pseudogene; Adhesion Inhibitory Receptor Molecule 1,
分子量： 51kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIGLEC7
交叉反应：Human,
细胞定位：细胞膜
唾液酸结合性**球蛋白样凝集素7抗体产品介绍：background: Siglec 7 is a member of the Siglec (sialic acid-binding immunoglobulin like lectin) subgroup of the immunoglobulin superfamily. Siglec 7 is able to mediate high levels of sialic acid-dependent binding to human erythrocytes and soluble sialoglycoconjugates. Addition of anti-Siglec 7 to haematopoietic cell cultures leads to reduced cell growth and prevents the development of dendritic cells. Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression can be found in tissues like the placenta, liver, lung, spleen, and peripheral blood leukocytes. Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be唾液酸结合性**球蛋白样凝集素7抗体 masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Predominantly expressed by resting and activated natural killer cells and at lower唾液酸结合性**球蛋白样凝集素7抗体 levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes. Post-translational modifications: Tyrosine phosphorylated. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 27036 Database links: Entrez Gene: 27036 Human Omim: 604410 Human SwissProt: Q9Y286 Human Unigene: 274470 Human Unigene: 655393 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
唾液酸结合性**球蛋白样凝集素7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 神经生物学 干细胞 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid