整合素α2抗体
规格：1mg/1ml
英文名： Integrin alpha 2/CD49b
别名： Integrin alpha 2; CD49b antigen; BR; CD 49b; CD49 antigen like family member B; CD49b; CD49b; Collagen receptor; DX5 ; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency, included; GPIa; HPA
分子量： 127kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Integrin
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞膜
整合素α2抗体产品介绍：background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides整合素α2抗体, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only 整合素α2抗体occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. Gene ID: 3673 Database links: Entrez Gene: 3673 Human Entrez Gene: 16398 Mouse Omim: 192974 Human SwissProt: P17301 Human SwissProt: Q62469 Mouse Unigene: 482077 Human Unigene: 5007 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素α2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid