Rho鸟甘酸转运蛋白抗体
规格：1mg/1ml
英文名： ARHGEF11
别名： PDZ-RhoGEF; PDZ RHOGEF; ARHGB_HUMAN; ARHGEF 11; ARHGEF11; DKFZp667F1223; Glutamate transporter EAAT4 associated protein 48; GTRAP 48; GTRAP48; PDZ RhoGEF; Rho guanine exchange factor (GEF) 11; Rho gua
分子量： 168kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ARHGEF11
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
Rho鸟甘酸转运蛋白抗体细胞定位：细胞浆 细胞膜
产品介绍：background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression Rho鸟甘酸转运蛋白抗体of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Subunit: Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Subcellular Location: Cytoplasm. Membrane. Rho鸟甘酸转运蛋白抗体Note=Translocated to the membrane upon stimulation. Tissue Specificity: Ubiquitously expressed. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 1 PH domain. Contains 1 RGSL (RGS-like) domain. Gene ID: 9826 Database links: Entrez Gene: 9826 Human Entrez Gene: 213498 Mouse Entrez Gene: 78966 Rat Omim: 605708 Human SwissProt: O15085 Human SwissProt: Q9ES67 Rat Unigene: 516954 Human Unigene: 160580 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Rho鸟甘酸转运蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid