乳腺癌转移抑制基因1抗体
规格：1mg/1ml
英文名： BRMS1
别名： AV003220;AW554636;Breast cancer metastasis suppressor 1 ; BRMS-1; BRMS1; BRMS 1; DKFZp564A063;MGC95128; BRMS1_HUMAN.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BRMS-1 C
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
乳腺癌转移抑制基因1抗体产品介绍：background: Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal 乳腺癌转移抑制基因1抗体breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-ⅹB activity. Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. Subunit: Belongs 乳腺癌转移抑制基因1抗体to the BRMS1 family. Subcellular Location: Nucleus. Cytoplasm. Predominantly nuclear. Tissue Specificity: Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. Post-translational modifications: Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. Similarity: Belongs to the BRMS1 family. Gene ID: 25855 Database links: Entrez Gene: 25855 Human Entrez Gene: 107392 Mouse Entrez Gene: 293668 Rat Omim: 606259 Human SwissProt: Q9HCU9 Human SwissProt: Q99N20 Mouse SwissProt: Q5M7T3 Rat Unigene: 100426 Human Unigene: 2839 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乳腺癌转移抑制基因1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid