Rho相关蛋白激酶2抗体
规格：1mg/1ml
英文名： ROCK1 + ROCK2
别名： p164 ROCK 2; p164 ROCK-2; Rho associated coiled coil containing protein kinase 2; Rho associated protein kinase 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha; coiled-coil-containing pr
分子量： 161kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ROCK1 an
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
Rho相关蛋白激酶2抗体产品介绍：background: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]. Function: Regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction. Subunit: Cytoplasm. Cell membrane. Cytoplasmic, and associated with actin microfilaments and the plasma membrane. Post-translational modifications:Rho相关蛋白激酶2抗体 Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Tyr-722 reduces its binding to RHOA and iscrucial for focal adhesion dynamics. Dephosphorylation by PTPN11stimulates its RHOA binding activity. Cleaved by granzyme B during apoptosis. This leads toconstitutive activation of the kinase and membrane blebbing. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. Contains 1 AGC-kinase C-terminal domain. Contains 1 PH domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. Contains 1 REM (Hr1) repeat. Gene ID: 6093 9475 Database links: Entrez Gene: 6093 Human Entrez Gene: 19877 Mouse Entrez Gene: Rho相关蛋白激酶2抗体81762 Rat Omim: 601702 Human SwissProt: Q13464 Human SwissProt: P70335 Mouse SwissProt: Q63644 Rat Unigene: 306307 Human Unigene: 6710 Mouse Unigene: 89756 Rat Entrez Gene: 9475 Human Entrez Gene: 19878 Mouse Entrez Gene: 25537 Rat Omim: 604002 Human SwissProt: O75116 Human SwissProt: P70336 Mouse SwissProt: Q62868 Rat Unigene: 58617 Human Unigene: 681743 Human Unigene: 276024 Mouse Unigene: 88642 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Rho相关蛋白激酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid