长寿相关基因lASS4抗体
规格：1mg/1ml
英文名： LASS4
别名： CerS4; LAG1 homolog ceramide synthase 4; LAG1 longevity assurance homolog 4; LASS 4; LASS4 LAG1 homolog ceramide synthase 4; Trh 1; Trh1; LASS4_HUMAN.
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LASS4
交叉反应：Human, Rat, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：
长寿相关基因lASS4抗体产品介绍：background: LASS4 is a member of the LASS (longevity assurance homologue) family which are involved in determining life span in yeast, by an unknown molecular mechanism. Members of this family are highly conserved from yeasts to mammals. Five mouse and human LASS family members, namely LASS1, LASS2, LASS4, LASS5 and LASS6, have been identified and characterized. LASS proteins are thought to be involved in ceramide synthesis. Overproduction of a single LASS protein results in an increase in one or长寿相关基因lASS4抗体 more specific ceramide species, which differ in fatty-acid chain length. LASS proteins possess specific fatty acyl-CoA preferences, but all can use sphingosine or dihydrosphingosine as the long-chain base substrate. LASS family members exhibit different tissue-specific expression patterns, which may contribute to the production of tissue-specific ceramides. Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors长寿相关基因lASS4抗体 (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. Subcellular Location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein. Similarity: Contains 1 homeobox DNA-binding domain. Contains 1 TLC (TRAM/LAG1/CLN8) domain. Gene ID: 79603 Database links: Entrez Gene: 79603 Human SwissProt: Q9HA82 Human Unigene: 515111 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
长寿相关基因lASS4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid