泛素样蛋白NEDD8抗体

泛素样蛋白NEDD8抗体

规格：1mg/1ml

英文名： NEDD8

别名： NED8; NEDD 8; Neddylin; Neural precursor cell expressed developmentally down regulated 8; Neural precursor cell expressed developmentally down regulated gene 8; Rub1; Ubiquitin like protein Nedd 8; Ub

分子量： 8.5kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human NEDD8

交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位：细胞核

泛素样蛋白NEDD8抗体产品介绍：background: Ubiquitin like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin, RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other. In contrast to UBLs, UDPs are not proteolytically processed or conjugated to other proteins. Rub1 and the corresponding human homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, 泛素样蛋白NEDD8抗体that forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to ubiquitin. The best known targets of Rub1 modification are members of the cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification may regulate SCF function or localization. Function: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Subunit: Directly interacts with泛素样蛋白NEDD8抗体 NUB1 and AHR. Covalently attached to cullins and p53. Subcellular Location: Nucleus. Note=Mainly nuclear. Tissue Specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. Post-translational modifications: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. Similarity: Belongs to the ubiquitin family. Gene ID: 4738 Database links: Entrez Gene: 35151 Fruit fly (Drosophila melanogaster) Entrez Gene: 4738 Human Entrez Gene: 18002 Mouse Entrez Gene: 25490 Rat Entrez Gene: 368667 Zebrafish Omim: 603171 Human SwissProt: Q9VJ33 Fruit fly (Drosophila melanogaster) SwissProt: Q15843 Human SwissProt: P29595 Mouse SwissProt: Q71UE8 Rat Unigene: 30848 Fruit fly (Drosophila melanogaster) Unigene: 531064 Human Unigene: 296566 Mouse Unigene: 216415 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

泛素样蛋白NEDD8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  **学  神经生物学  信号转导  转录调节因子  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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