细胞质膜微囊蛋白-2抗体
规格：1mg/1ml
英文名： Caveolin-2
别名： CAV; CAV2; CAV2_HUMAN; Caveolae protein 20 kD; Caveolin 2; Caveolin2; Caveolin 2 isoform a and b; Caveolin 2 isoform c; Caveolin-2; MGC12294.
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Caveolin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞质膜微囊蛋白-2抗体细胞定位：细胞核 细胞浆 细胞膜
产品介绍：background: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of 细胞质膜微囊蛋白-2抗体the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. Subunit: Monomer or homodimer. Subcellular Location: Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Tissue Specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. Post-translational modifications: Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 细胞质膜微囊蛋白-2抗体and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin. Similarity: Belongs to the caveolin family. Gene ID: 858 Database links: Entrez Gene: 858 Human Entrez Gene: 12390 Mouse Entrez Gene: 100362824 Rat Entrez Gene: 363425 Rat Omim: 601048 Human SwissProt: O46550 Dog SwissProt: P51636 Human SwissProt: Q9WVC3 Mouse SwissProt: Q2IBC5 Rat Unigene: 212332 Human Unigene: 603096 Human Unigene: 396075 Mouse Unigene: 81070 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞质膜微囊蛋白-2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid