胃粘液素抗体
规格：1mg/1ml
英文名： Mucin 5AC
别名： MUC5AC; Mucin-5AC; MUC5AC Glycoprotein; Mucin 5AC oligomeric mucus/gel forming; Apomucin; Gastric mucin; Major Airway Glycoprotein; MUC 5; MUC5; MUC5AC; Mucin 5 subtype AC tracheobronchial; Mucin 5 Su
分子量： 683kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Mucin 5A
交叉反应：Human,
细胞定位：细胞浆 细胞膜 细胞外基质 分泌型蛋白
胃粘液素抗体产品介绍：background: Mucin is a high M.W. (>1,000 kDa) glycoprotein, expressed by mucus cells of the gastric epithelium and by goblet cells of the fetal, precancerous and cancerous colon, but not by those of the normal colon. It also appears in other epithelial tissues, which are embryologically derived from the foregut (epigastric and bronchial epithelium) and in Müller ducts (mucus cells of the endocervix and urethral epithelium near the prostatic utriculus). The expression of MUC5AC has been frequently observed in gastric carcinomas and may be used as a marker of gastric differentiation. Function: Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. Subunit: Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).胃粘液素抗体 Subcellular Location: Secreted. Tissue Specificity: Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. Post-translational modifications: C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway.胃粘液素抗体 Cleavage generates a reactive group which could link the protein to a primary amide. Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 2 VWFC domains. Contains 4 VWFD domains. Gene ID: 4586 Database links: Entrez Gene: 4586 Human Entrez Gene: 17833 Mouse Entrez Gene: 682837 Rat Omim: 158373 Human SwissProt: P98088 Human Unigene: 534332 Human Unigene: 10789 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胃粘液素抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid