巨噬细胞移动抑制因子抗体
规格：1mg/1ml
英文名： MIF
别名： Macrophage Migration Inhibitory Factor; GIF; GLIF; Glycosylation inhibiting factor; MIF protein; MMIF; Phenylpyruvate tautomerase; acrophage migration inhibitory factor (glycosylation-inhibiting facto
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIF
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞浆 分泌型蛋白
巨噬细胞移动抑制因子抗体产品介绍：background: This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008] Function: Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate 巨噬细胞移动抑制因子抗体tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. Subunit: Homotrimer. Interacts with CXCR2 extracellular domain. Interacts with the CD74 extracellular domain, COPS5 and BNIPL. Subcellular Location: Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. DISEASE: Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16巨噬细胞移动抑制因子抗体. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Similarity: Belongs to the MIF family. Gene ID: 4282 Database links: Entrez Gene: 4282 Human Entrez Gene: 17319 Mouse Entrez Gene: 81683 Rat Omim: 153620 Human SwissProt: P14174 Human SwissProt: P34884 Mouse SwissProt: P30904 Rat Unigene: 407995 Human Unigene: 2326 Mouse Unigene: 2661 Rat Unigene: 2326 Mouse Unigene: 2661 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
巨噬细胞移动抑制因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 生长因子和** 转录调节因子 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid