肝细胞生长因子α抗体
规格：1mg/1ml
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HGF alph
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：
肝细胞生长因子α抗体产品介绍：background: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the lasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative肝细胞生长因子α抗体 splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond. DISEASE: Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily. Contains 4 kringle domains. Contains 肝细胞生长因子α抗体1 PAN domain. Contains 1 peptidase S1 domain. Gene ID: 3082 Database links: Entrez Gene: 3082 Human Entrez Gene: 282879 Cow Entrez Gene: 15234 Mouse Entrez Gene: 24446 Rat Omim: 142409 Human SwissProt: Q9BH09 Cat SwissProt: Q76BS1 Cow SwissProt: Q867B7 Dog SwissProt: P14210 Human SwissProt: Q08048 Mouse SwissProt: P17945 Rat Unigene: 396530 Human Unigene: 267078 Mouse Unigene: 10468 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肝细胞生长因子（HGF)是一种多肽生长因子，具有促进包括肝细胞、上皮细胞、内皮细胞、造血细胞等多种类型细胞的生长、迁移和形态发生的作用. 它还参与多种细胞的增殖、迁移,对各类肿瘤的侵袭转移有着重要的诱导作用. HGF除了由肝脏大量产生并释放进入血液，还可从胚胎肺成纤维细胞株中分离得到，因此又称扩散因子（scatter factor）或称肺成纤维细胞衍生生长因子（fibroblast-derived growth factor）。
肝细胞生长因子α抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid