B**细胞受体相关蛋白抗体
规格：1mg/1ml
英文名： REA
别名： B cell receptor associated protein BAP37; B-cell associated protein; B-cell receptor-associated protein BAP37; Bap 37; BAP; Bap37; BCAP 37; BCAP37; D prohibitin; D-prohibitin; MGC117268; p22; PHB 2; P
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human REA
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
B**细胞受体相关蛋白抗体产品介绍：background: The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in nuclear and mitochondrial compartments in eukaryotic cells and exert multiple cellular functions (1). PHB2 (REA) was originally identified as an estrogen receptor (ER) specific coregulator. It directly interacts with hormone-bound ER and represses its transcriptional activity by competitive inhibition of SRC-1 coactivation of ER (2,3). Together with COUP-TFs, PHB2 also interacts with histone deacetylases HDAC1 and HDAC5, and mediates transcriptional regulation by ER through coupling the deacetylase to the transcription activation complex (4). Another important function of PHB2 is stablization of mitochondrial proteins. PHB1/PHB2 hetrodimers form large ring complexes on the mitochondrial membrane (5),B**细胞受体相关蛋白抗体 acting as chaperones to stablize important mitochodrial proteins, such as OPA1 and Hax1 to support mitochondrial morphogenesis and protection against apoptosis (6-8). Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating B**细胞受体相关蛋白抗体mitochondrial respiration activity and in aging. Subunit: Interacts with PHB, ESR1, HDAC1 and HDAC5. Interacts with ZNF703. Subcellular Location: Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear. Similarity: Belongs to the prohibitin family. Gene ID: 11331 Database links: Entrez Gene: 11331 Human Entrez Gene: 12034 Mouse Entrez Gene: 114766 Rat Omim: 610704 Human SwissProt: Q99623 Human SwissProt: O35129 Mouse SwissProt: Q5XIH7 Rat Unigene: 504620 Human Unigene: 36241 Mouse Unigene: 64535 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
B**细胞受体相关蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid