生长抑制DNA损伤基因34抗体
规格：1mg/1ml
英文名： GADD34
别名： Growth arrest and DNA damage-inducible 34; Apoptosis associated protein; GADD 34; Growth arrest and DNA damage inducible 34; Growth arrest and DNA-damage-inducible 34; PPP1R15A; Protein phosphatase 1
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GADD34
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
生长抑制DNA损伤基因34抗体产品介绍：background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] Function: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells 生长抑制DNA损伤基因34抗体from stress. Subunit: Interacts with PCNA. Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. Subcellular Location: Endoplasmic reticulum. Post-translational modifications: Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Similarity: Belongs to the PPP1R15 family. Gene ID: 23465 Database links: Entrez Gene:生长抑制DNA损伤基因34抗体 514688 Cow Entrez Gene: 23645 Human Entrez Gene: 17872 Mouse Entrez Gene: 171071 Rat Omim: 611048 Human SwissProt: Q2KI51 Cow SwissProt: O75807 Human SwissProt: P17564 Mouse SwissProt: Q6IN02 Rat Unigene: 631593 Human Unigene: 4048 Mouse Unigene: 2232 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长抑制DNA损伤基因34抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid