磷酸化突触融合蛋白1抗体
规格：1mg/1ml
英文名： phospho-Syntaxin 1a(Ser188)
别名： Syntaxin 1a (phospho S188); Syntaxin 1a (phospho Ser188); p-Syntaxin 1a (Ser188); HPC 1; Neuron specific antigen HPC1; Neuron-specific antigen HPC-1; OTTHUMP; OTTHUMP; OTTHUMP000
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig,
细胞定位：细胞膜
磷酸化突触融合蛋白1抗体产品介绍：background: Syntaxin 1a is potentially involved in docking of synaptic vesicles at presynaptic active zones and may play a critical role in neurotransmitter exocytosis. Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Subunit: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25. Interacts with OTOF and LGI3. Interacts with SLC6A4. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU. Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell 磷酸化突触融合蛋白1抗体junction, synapse, synaptosome. Isoform 2: Secreted (Probable). Tissue Specificity: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in ***** cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. Post-translational modifications: Phosphorylated by DAPK1. DISEASE: Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Similarity: Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain. Gene ID: 6804 Database links: Entrez Gene: 6804 Human Entrez Gene: 20907 Mouse Entrez Gene: 116470 Rat 磷酸化突触融合蛋白1抗体Omim: 186590 Human SwissProt: P32850 Cow SwissProt: Q16623 Human SwissProt: O35526 Mouse SwissProt: Q5R4L2 Orangutan SwissProt: P32851 Rat Unigene: 647024 Human Unigene: 6225 Mouse Unigene: 9943 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化突触融合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 转录调节因子 转运蛋白 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid