干扰素诱导跨膜蛋白1抗体
规格：1mg/1ml
英文名： IFITM1
别名： CD225; CD225 antigen; CD 225; CD-225; IFI17; Interferon induced protein 17; Interferon induced transmembrane protein 1; Interferon inducible protein 9-27; Interferon-induced protein 17; Interferon-ind
分子量： 11.7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IFITM1
交叉反应：Human, Mouse, Rat,
干扰素诱导跨膜蛋白1抗体细胞定位：细胞膜
产品介绍：background: IFITM1 expression is induced by interferons alpha and gamma and it is thought to play a role in control of cell growth. It is upregulated in several tumor types and may be useful as a tumor biomarker. Function: IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or干扰素诱导跨膜蛋白1抗体 by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals. Subunit: Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity 干扰素诱导跨膜蛋白1抗体against influenza virus. Similarity: Belongs to the CD225 family. Gene ID: 8519 Database links: Entrez Gene: 8519 Human Entrez Gene: 68713 Mouse Entrez Gene: 293618 Rat Omim: 604456 Human SwissProt: P13164 Human SwissProt: Q9D103 Mouse Unigene: 458414 Human Unigene: 175661 Mouse Unigene: 22087 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IFITM1蛋白是蛋白复合物的组分之一,主要功能是参与同型粘附和抗增殖信号的转导,与细胞增殖、肿瘤分化、抗病毒、**监视等有关。IFITM-1主要用于消化系统肿瘤方面的研究，有学者认为：干扰素诱导跨膜蛋白1与干扰素结合，可以抑制肿瘤细胞的分化和增值。
干扰素诱导跨膜蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid