A型流感病毒H3N2-M2蛋白抗体
规格：1mg/1ml
英文名： H3N2 Matrix Protein 2
别名： H3N2, matrix protein 2 [Influenza A virus (A/(A/Thailand/CU23/2006(H3N2))]; M2_I72A2; Matrix protein 2; Proton channel protein M2; M; [Influenza A virus (A/Udorn/307/1972(H3N2))].
分子量： 11kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human H3N2 Mat
交叉反应：Influenza A virus H3N2
细胞定位：
A型流感病毒H3N2-M2蛋白抗体产品介绍：background: Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997,A型流感病毒H3N2-M2蛋白抗体 an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species jumping ability. Function: Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin A型流感病毒H3N2-M2蛋白抗体from premature switching to the fusion-active conformation. Subunit: Homotetramer; composed of two disulfide-linked dimmers held together by non-covalent interactions. May interact with matrix protein 1. Subcellular Location: Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion). Similarity: Belongs to the influenza viruses matrix protein M2 family. Database links: UniProtKB/Swiss-Prot: P63231.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
A型流感病毒H3N2-M2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid