神经酰胺激酶CERK抗体
规格：1mg/1ml
英文名： CERK
别名： Acylsphingosine kinase; Ceramide kinase; hCERK; KIAA1646; Lipid kinase 4; LK4; Cerk; CERK1_HUMAN.
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CERK
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 细胞膜
神经酰胺激酶CERK抗体产品介绍：background: Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart,神经酰胺激酶CERK抗体 brain, skeletal muscle, kidney and liver; moderate expression in peripheral blood leukocytes and thymus; and low expression in spleen, small intestine, placenta and lung. Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Tissue Specificity: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung. Similarity: Contains 1 DAGKc domain. Gene ID: 64781 Database links: Entrez神经酰胺激酶CERK抗体 Gene: 64781 Human Entrez Gene: 223753 Mouse Entrez Gene: 300129 Rat Omim: 610307 Human SwissProt: Q8TCT0 Human SwissProt: Q8K4Q7 Mouse Unigene: 200668 Human Unigene: 222685 Mouse Unigene: 99537 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经酰胺激酶CERK抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid