α横纹肌辅肌动蛋白/α-SCA抗体
规格：1mg/1ml
英文名： Sarcomeric Alpha Actinin
别名： Actin binding protein; Actinin alpha 2; ACTN 2; ACTN2; ACTN2_HUMAN; Alpha actinin 2; Alpha actinin skeletal muscle; Alpha actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 2; Al
分子量： 98kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Sarcomer
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
α横纹肌辅肌动蛋白/α-SCA抗体产品介绍：Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Subunit: Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Subcellular Location: Cytoplasm, myofibril, sarcomere, Z line. α横纹肌辅肌动蛋白/α-SCA抗体Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. Tissue Specificity: Expressed in both skeletal and cardiac muscle. Post-translational modifications: Ubiquitinated by FBXL22, leading to proteasomal degradation. DISEASE: Cardiomyopathy, dilated 1AA (CMD1AA) [MIM:612158]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the alpha-actinin family. Contains 1 actin-binding domain. Contains 2 CH (calponin-homology) domains. Contains 2 EF-hand domains. Contains α横纹肌辅肌动蛋白/α-SCA抗体4 spectrin repeats. Database links: UniProtKB/Swiss-Prot: P35609.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
α横纹肌辅肌动蛋白/α-SCA抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid