磷酸化认知缺陷突触相关蛋白SynGAP抗体
规格：1mg/1ml
英文名： phospho-SynGAP (Ser836)
别名： SynGAP (phospho S836); SynGAP (phospho Ser836); p-SynGAP (Ser836); p-RASA1(Ser836); Neuronal RasGAP; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RA
分子量： 148kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：
磷酸化认知缺陷突触相关蛋白SynGAP抗体产品介绍：background: The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway. Function: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent 磷酸化认知缺陷突触相关蛋白SynGAP抗体control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. Subunit: Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ. Post-translational modifications: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. DISEASE: Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental 磷酸化认知缺陷突触相关蛋白SynGAP抗体delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients. Similarity: Contains 1 C2 domain. Contains 1 PH domain. Contains 1 Ras-GAP domain. Gene ID: 8831 Database links: Entrez Gene: 8831 Human Entrez Gene: 240057 Mouse Entrez Gene: 192117 Rat Omim: 603384 Human SwissProt: Q96PV0 Human SwissProt: Q9QUH6 Rat Unigene: 586264 Human Unigene: 9908 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化认知缺陷突触相关蛋白SynGAP抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid