辛酰基化脑肠肽抗体
规格：1mg/1ml
英文名： Ghrelin 28 (n-octanoyl Ser26)
别名： Ghrelin 28 [Ser26 (n-octanoyl)]; Appetite regulating hormone; Ghrelin 27; Ghrelin 28; Ghrelin/obestatin prepropeptide; GHRL; Growth hormone releasing peptide; Growth hormone secretagogue; M46 protein;
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised n-octanoyl-peptide derived from h
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：分泌型蛋白
辛酰基化脑肠肽抗体产品介绍：background: This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008]. Function: Ghrelin is the ligand for growth hormone secretagogue辛酰基化脑肠肽抗体 receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. Subcellular Location: Secreted. Tissue Specificity: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy. Post-translational modifications: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity. Similarity: Belongs to the motilin family.辛酰基化脑肠肽抗体 Gene ID: 51738 Database links: Entrez Gene: 51738 Human Entrez Gene: 58991 Mouse Entrez Gene: 59301 Rat Entrez Gene: 574280 Rhesus monkey Omim: 605353 Human SwissProt: Q6BEG6 Cat SwissProt: Q9BEF8 Dog SwissProt: Q9UBU3 Human SwissProt: Q9EQX0 Mouse SwissProt: Q9GKY5 Pig SwissProt: Q9QYH7 Rat Unigene: 590080 Human Unigene: 672979 Human Unigene: 379095 Mouse Unigene: 42103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
辛酰基化脑肠肽抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 生长因子和** 糖尿病 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid