Ras蛋白特异鸟嘌呤核苷酸释放因子1抗体
规格：1mg/1ml
英文名： Rasgrp1
别名： Calcium and DAG-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CALDAG-GEFII; Guanine nucleotide exchange factor, calcium and DAG regulated, Rap1A; hRasGRP1; Ras activator RasGRP; RAS gu
分子量： 90kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Rasgrp1
交叉反应：Human, Mouse, Rat, Dog, Rabbit,
细胞定位：细胞膜 细胞外基质
Ras蛋白特异鸟嘌呤核苷酸释放因子1抗体产品介绍：background: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]. Function: RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. Subunit: Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1. SubcellularRas蛋白特异鸟嘌呤核苷酸释放因子1抗体 Location: Cell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus. Found in membrane fraction. Relocalization to the cell membrane upon activation is F-actin-dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Tissue Specificity: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Post-translational modifications: Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Note=Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this Ras蛋白特异鸟嘌呤核苷酸释放因子1抗体signaling protein contributes to the development of autoimmunity in a subset of SLE patients. Similarity: Belongs to the RASGRP family. Contains 2 EF-hand domains. Contains 1 N-terminal Ras-GEF domain. Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Ras-GEF domain. Gene ID: 10125 Database links: Entrez Gene: 10125 Human Entrez Gene: 19419 Mouse Omim: 603962 Human SwissProt: O95267 Human SwissProt: Q9Z1S3 Mouse Unigene: 591127 Human Unigene: 42150 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ras蛋白特异鸟嘌呤核苷酸释放因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 结合蛋白 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid