癌/睾丸抗原113抗体
规格：1mg/1ml
英文名： Tex14
别名： Cancer/testis antigen 113; CT113; Inactive serine/threonine protein kinase TEX14; SGK307; Protein kinase like protein SgK307; Sugen kinase 307; Testis expressed Protein 14; Testis expressed sequence 1
分子量： 168kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Tex14
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞核 细胞浆
癌/睾丸抗原113抗体产品介绍：background: TEX14 is a 1,497 amino acid protein that belongs to the protein kinase superfamily and is expressed in testis. The gene encoding TEX14 is located on chromosome 17 and is required for spermatogenesis and normal structure of the intercellular bridge that connects spermatocytes and spermatogonia. TEX14 co-localizes with the centralspindlin complex, MKLP-1 (mitotic kinesin-like protein 1) and male germ cell Rac GTPase (Rac GTPase-activating protein) and converts these midbody matrix proteins into stable intercellular bridge components. TEX14 contains 3 ANK repeats and 1 protein kinase domain. Three isoforms exist due to alternative splicing events. Function: Testis-expressed gene 14 (TEX14) is a novel protein that localizes to germ cell intercellular bridges. In the absence of TEX14, intercellular bridges are 癌/睾丸抗原113抗体not observed. Spermatogenesis in Tex14–/– mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division. Subunit: Interacts with KIF23 and RBM44. Interacts with CEP55; inhibiting interaction between CEP55 and PDCD6IP/ALIX and TSG101 Subcellular Location: Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. Tissue Specificity: Detected in testis. Post-translational modifications: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-437 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. Similarity: Belongs to the protein kinase superfamily. Contains 3 ANK repeats. Contains 1癌/睾丸抗原113抗体 protein kinase domain. Gene ID: 56155 Database links: Entrez Gene: 522810 Cow Entrez Gene: 56155 Human Entrez Gene: 83560 Mouse Omim: 605792 Human SwissProt: F1MJR8 Cow SwissProt: Q8IWB6 Human SwissProt: Q7M6U3 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
癌/睾丸抗原113抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 发育生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid