富含亮氨酸重复结构域蛋白6抗体
规格：1mg/1ml
英文名： NALP6
别名： CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NALP6_HUMAN; NLR family, pyrin domain containing 6;
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NALP6
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆 细胞膜
富含亮氨酸重复结构域蛋白6抗体产品介绍：background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes富含亮氨酸重复结构域蛋白6抗体(Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] Function: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine-vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Subunit: Binds to ASC with its DAPIN domain. Subcellular Location: Isoform 1: Cytoplasm. Cell membrane富含亮氨酸重复结构域蛋白6抗体. Nucleus membrane. Isoform 2: Cytoplasm. Cell membrane. Note=Predominantly expressed in the cell membrane. Tissue Specificity: Highly expressed in the small and large intestine, kidney and liver. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 3 LRR (leucine-rich) repeats. Contains 1 NACHT domain. Gene ID: 171389 Database links: Entrez Gene: 171389 Human Omim: 609650 Human SwissProt: P59044 Human Unigene: 352611 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸重复结构域蛋白6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid