巨噬细胞炎症因子1α抗体 MIP-1α
规格：1mg/1ml
英文名： CCL3
别名： Tonsillar lymphocyte LD78 alpha protein; CCL 3; CCL3; Chemokine C C motif ligand 3; Chemokine CC Motif Ligand 3; G0/G1 switch regulatory protein 19 1; G0S19 1; G0S19 1 protein; Heparin binding chemota
分子量： 7.5/7.7kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MIP-1 al
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
巨噬细胞炎症因子1α抗体 MIP-1α产品介绍：background: Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the巨噬细胞炎症因子1α抗体 MIP-1α C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated. Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Subunit: Self-associates. Also heterodimer of MIP-1-alpha(4-69) 巨噬细胞炎症因子1α抗体 MIP-1αand MIP-1-beta(3-69). Subcellular Location: Secreted. Post-translational modifications: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. Similarity: Belongs to the intercrine beta (chemokine CC) family. Gene ID: 6348 Database links: Entrez Gene: 6348 Human Entrez Gene: 20302 Mouse Entrez Gene: 25542 Rat Omim: 182283 Human SwissProt: P10147 Human SwissProt: P10855 Mouse SwissProt: P50229 Rat Unigene: 514107 Human Unigene: 1282 Mouse Unigene: 10139 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 巨噬细胞炎症蛋白1α（MIP-1α）是CC趋化因子中的一种。主要用于炎症、肿瘤方面的研究。
巨噬细胞炎症因子1α抗体 MIP-1α产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid