DAP凋亡诱导蛋白激酶2抗体
规格：1mg/1ml
英文名： DRAK2
别名： DAP kinase related apoptosis inducing protein; DAP kinase related apoptosis inducing protein kinase 2; Death associated protein kinase related 2; DRAK 2; Serine/threonine kinase 17b (apoptosis inducin
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DRAK2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
DAP凋亡诱导蛋白激酶2抗体产品介绍：background: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis DAP凋亡诱导蛋白激酶2抗体through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues. Function: Acts as a positive regulator of apoptosis. Subunit: Interacts with CHP1; the interaction induces CHP1 to translocate from the Golgi to the nucleus. Subcellular Location: Nucleus. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=Colocalizes with STK17B at the plasma membrane. Tissue Specificity: Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver,DAP凋亡诱导蛋白激酶2抗体 skeletal muscle and kidney. Post-translational modifications: Autophosphorylated. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. Contains 1 protein kinase domain. Gene ID: 9262 Database links: Entrez Gene: 9262 Human Entrez Gene: 98267 Mouse Omim: 604727 Human SwissProt: O94768 Human SwissProt: Q8BG48 Mouse Unigene: 88297 Human Unigene: 25559 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DAP凋亡诱导蛋白激酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid