胞浆动力蛋白中间链1抗体
规格：1mg/1ml
英文名： DYNC1I1
别名： dynein, cytoplasmic, intermediate polypeptide 1; cytoplasmic dynein 1 intermediate chain 1; DH IC-1; dynein intermediate chain 1, cytosolic; cytoplasmic dynein intermediate chain 1; DC1I1_HUMAN; DYNC1
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DYNC1I1
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
胞浆动力蛋白中间链1抗体产品介绍：background: The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008]. Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.胞浆动力蛋白中间链1抗体 The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. Subunit: Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1. Subcellular胞浆动力蛋白中间链1抗体 Location: Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Similarity: Belongs to the dynein intermediate chain family. Contains 7 WD repeats. Gene ID: 27019 Database links: Entrez Gene: 27019 Human Entrez Gene: 68922 Mouse Entrez Gene: 500442 Rat Omim: 603772 Human SwissProt: Q9UI46 Human SwissProt: Q8C0M8 Mouse SwissProt: Q5XIL8 Rat Unigene: 112667 Human Unigene: 79127 Mouse Unigene: 93980 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胞浆动力蛋白中间链1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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