乙酰肝素酶2抗体
规格：1mg/1ml
英文名： Heparanase 2/HPSE2
别名： heparanase 2; heparanase 3; Heparanase-2; Heparanase 2; heparanase-like protein; Hpa2; HPR2; HPSE2; HPSE2_HUMAN; UFS; Inactive heparanase-2.
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Heparana
交叉反应：Human, Mouse, Rat,
细胞定位：
乙酰肝素酶2抗体产品介绍：background: This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Function: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Subunit: Interacts with HPSE. Interacts with SDC1 (via glycan chains). Subcellular Location: 乙酰肝素酶2抗体Secreted, extracellular space, extracellular matrix. Tissue Specificity: Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. DISEASE: Urofacial syndrome 1 (UFS1) [MIM:236730]: A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or 乙酰肝素酶2抗体overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the glycosyl hydrolase 79 family. Database links: NCBI Reference Sequence: NP_068600.4 UniProtKB/Swiss-Prot: Q8WWQ2.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
乙酰肝素酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid