平足蛋白/**管内皮细胞蛋白抗体
规格：1mg/1ml
英文名： Podoplanin
别名： Podoplanin /gp36; Podoplanin Protein; AGGRUS; GLYCOPROTEIN 36 KD; Podoplanin; Glycoprotein 36; gp 36; GP 38; GP 40; gp36; GP38; GP40; HT1A 1; HT1A1; hT1alpha1; hT1alpha2; Lung type I cell membrane ass
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Podoplan
交叉反应：Mouse, Rat,
细胞定位：细胞浆 细胞膜
平足蛋白/**管内皮细胞蛋白抗体产品介绍：background: This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth.平足蛋白/**管内皮细胞蛋白抗体 Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Subcellular Location: Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. Tissue Specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.平足蛋白/**管内皮细胞蛋白抗体 Post-translational modifications: Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity. The N-terminus is blocked. Similarity: Belongs to the podoplanin family. Gene ID: 14726 Database links: Entrez Gene: 10630 Human Entrez Gene: 14726 Mouse Entrez Gene: 54320 Rat Omim: 608863 Human SwissProt: Q86YL7 Human SwissProt: Q62011 Mouse SwissProt: Q64294 Rat Unigene: 468675 Human Unigene: 2976 Mouse Unigene: 794 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Podoplanin Protein是一种肾小球足状突细胞膜粘蛋白，目前已成为一种新的**管内皮标记物蛋白，在少数小静脉上也有表达。 podoplanin Protein是**管内皮高度敏感且特异性的标记物，作为肿瘤细胞的血小板聚集介导因子而发挥作用，能促进肿瘤细胞迁移及增加肿瘤细胞侵袭力。
平足蛋白/**管内皮细胞蛋白抗体产品应用：IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 **细胞 内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid