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磷酸化抑癌蛋白EZH2抗体

磷酸化抑癌蛋白EZH2抗体
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  • 产品名称:磷酸化抑癌蛋白EZH2抗体
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简单介绍
磷酸化抑癌蛋白EZH2抗体应用于IHC、WB、 IF、IP、ELISA���科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。磷酸化抑癌蛋白EZH2抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。
产品描述

磷酸化抑癌蛋白EZH2抗体

规格:1mg/1ml

英文名: phospho-KMT6 (Ser21)

别名: KMT6 / EZH2 (phospho S21); KMT6 / EZH2 (phospho S21); KMT6/EZH2 (phospho Ser21); p-KMT6/EZH2 (Ser21); p-KMT6/EZH2 (S21); Enhancer of zeste homolog 2; Enx1h; MGC9169; Enhancer of zeste 2; ENX-1; ENX 1;

分子量: 82kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated Synthesised phosphopeptide derived from human

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Xenopus laevis, Zebrafish,

细胞定位:细胞核

磷酸化抑癌蛋白EZH2抗体产品介绍:background: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]. Function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.磷酸化抑癌蛋白EZH2抗体 Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4. Subunit: Binds ATRX via the SET domain (Probable). Component of the PRC2/EED-EZH2 complex, which includes EED, EZH2, SUZ12, RBBP4 and RBBP7 and possibly AEBP2. The minimum components required for methyltransferase activity of the PRC2/EED-EZH2 complex are EED, EZH2 and SUZ12. The PRC2 complex may also interact with DNMT1, DNMT3A, DNMT3B and PHF1 via the EZH2 subunit and with SIRT1 via the SUZ12 subunit. Interacts with HDAC1 and HDAC2. Interacts with PRAME. Subcellular Location: Nucleus. Tissue Specificity: Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis. Post-translational modifications: Phosphorylated by AKT1. Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing. Sumoylated. Similarity: Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1磷酸化抑癌蛋白EZH2抗体 CXC domain. Contains 1 SET domain. Gene ID: 2146 Database links: Entrez Gene: 2146 Human Entrez Gene: 14056 Mouse Entrez Gene: 100381148 Xenopus laevis Entrez Gene: 399174 Xenopus laevis Entrez Gene: 768133 Zebrafish Omim: 601573 Human SwissProt: Q15910 Human SwissProt: Q61188 Mouse SwissProt: Q4V863 Xenopus laevis SwissProt: Q98SM3 Xenopus laevis SwissProt: Q08BS4 Zebrafish Unigene: 444082 Human Unigene: 246688 Mouse Unigene: 19136 Xenopus laevis Unigene: 47646 Xenopus laevis Unigene: 76424 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷酸化抑癌蛋白EZH2抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:**学  微生物学  b-**细胞  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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