内质网蛋白44抗体
规格：1mg/1ml
英文名： TXNDC4
别名： Endoplasmic reticulum resident protein 44; Endoplasmic reticulum resident protein 44 kDa; Endoplasmic reticulum resident protein ERp44; ER protein 44; ERP44; KIAA0573; PDIA10; Protein disulfide isomer
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TXNDC4
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞浆
内质网蛋白44抗体产品介绍：background: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Function: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved 内质网蛋白44抗体CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Subunit: Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. Subcellular Location: Endoplasmic reticulum lumen. Similarity: Contains 内质网蛋白44抗体 thioredoxin domain. Gene ID: 23071 Database links: Entrez Gene: 23071 Human Entrez Gene: 506157 Cow Entrez Gene: 474781 Dog Entrez Gene: 100414815 Marmoset (common) Entrez Gene: 76299 Mouse Entrez Gene: 100192437 Pig Entrez Gene: 298066 Rat Omim: 609170 Human SwissProt: Q3T0L2 Cow SwissProt: Q9BS26 Human SwissProt: Q9D1Q6 Mouse Unigene: 154023 Human Unigene: 317701 Mouse Unigene: 2459 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
内质网蛋白44抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 染色质和核信号 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid