间隙连接蛋白40抗体
规格：1mg/1ml
英文名： Connexin-40
别名： connexin 40; connexin40; CX40; Gap junction alpha 5 protein; gap junction protein alpha 5 40kD (connexin 40); gap junction protein alpha 5; GJA5; MGC11185; CXA5_HUMAN; Gap junction alpha-5 protein; Co
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Connexin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
间隙连接蛋白40抗体产品介绍：background: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008] Function: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Subunit: A connexon is composed of a hexamer of connexins. Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. DISEASE: Familial atrial standstill间隙连接蛋白40抗体 (FAS) [MIM:108770]: Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. A rare GJA5 genotype has been detected in combination with a mutation in SCN5A in a large family with atrial standstill. Familial atrial fibrillation 11 (ATFB11) [MIM:614049]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical 间隙连接蛋白40抗体activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the connexin family. Alpha-type (group II) subfamily. Gene ID: 2702 Database links: Entrez Gene: 2702 Human Omim: 121013 Human SwissProt: P36382 Human Unigene: 447968 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Cx40间隙连接蛋白40 是构成细胞间的通道，小分子成份可以借此在细胞间扩散。Connexin-40也是心肌缝隙连接的主要蛋白之一。 此外，星形细胞、成纤维细胞、平滑肌和肾等组织也有表达Connexin40。
间隙连接蛋白40抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid